fatprofile - profilo lipidomico

medico specialistaFatprofile® is a  fundamental support for prevention, therapy and implementation of the quality of life.

With the lipidomic analysis FAT PROFILE® a dynamic view of the cell membrane is achieved which derives from several factors: life style, individual metabolism, unbalanced diet, or a cell stress status. The loss of the normal values, caused by enzymatic, metabolic or dietary deficiencies, can start a situation of cell impairment, even without evident signs of diseases.

With the FAT PROFILE® the main fatty acids for the cell functions and metabolism are evaluated, together with the endogenous TRANS LIPIDS, i.e., the trans lipids that are formed by the intervention of free radical species on cell membranes. In particular, thetrans isomers of arachidonic acid have been exclusively developed by Lipinutragen, the only company in the market to have the molecular library for recognition in biological samples. This additional element is of fundamental importance in case that a cause of cell stress o inflammation has to be evidenced and evaluated.

The FAT PROFILE® is focused on erythrocyte membranes because the organism is choosing the best conditions for this type of membranes, trying to keep the optimal levels of permeability and fluidity properties in order to favor cellular exchanges.
These membrane lipids come from the diet and also from the individual biosynthetic capabilities.

membrana LipinutragenHow is FAT PROFILE® executed?
A blood sample from venous withdrawal in EDTA (2 cc are enough), sent to the Lipidomic Laboratory at Lipinutragen, will be processed and analysed together withfilling a questionnaire with anamnesis and dietary habits.


The response of the FAT PROFILE® is a lipidomic report, which consists of:

  • A table with the percent values of the fatty acids found in the erythrocyte membrane of the patient compared to the normal intervals In this table some unbalance indicators are reported, such as the saturated/monounsaturated fatty acid ratio (SFA/MUFA) and the omega-6 and omega-3 fatty acid ratio (omega6/omega3), which are useful to monitor the lipid balance among some membrane components. There are also the TRANS LIPIDS that are markers of free radical stress;
  • A graph with a color scale together with the MUI Index (MUI –Membrane Unbalance Index) which describe, in a simple and effective manner, the global condition of unbalance found in the individual cell membranes;

If needed, a nutraceutical suggestion together with dietary indications to synergize with the therapeutic intervention.

It is worth underlining that to carry out the membrane lipidomics it is necessary to make the work-up of the blood sample, in order to isolate the membrane phospholipids and examine the fatty acid content.

The choice of focusing on the cell membrane is explained by the fact that the normal fatty acid intervals for membrane lipids are known, and they are constant during a long term period, if there are not variations of the metabolism and nutrition that last more than 3-4 months (based on the 120 days of the mean life time of the erythrocyte).

 

 

It is very difficult to create a table for the normal lipid levels of other compartments describing the normal values, because the circulating lipids are variable depending from the diet of the days o weeks before the analysis. The lipidomic evaluation using the plasma lipids, as well as the lipids obtained from the whole blood, gives information that are not focused on the metabolic and functional status of membranes.

The FAT PROFILE® allows a specific group of molecules to be monitored (phospholipids) which play a very important role in the cell membrane organization and functioning (in particular, the erythrocyte membrane), being membranes a biological compartment which aims at maintaining its structure and functions despite the changes and transformations of the surrounding conditions. Therefore, the type and entity of the variations that are observed in the membrane samples take on a more important biological and metabolic meaning.

The FAT PROFILE® is applicable to the personalization of the diagnostic-therapeutic approach.
It is also possible to apply it to the evaluation of the status of groups of patients having a homogeneous situation (such as the follow-up of the effects of treatments) that can be achieved by comparing the status of the erythrocyte membrane of the studied group compared with the control group, available in the lipidomic data base at Lipinutragen. In this context, Lipinutragen offers its consultancy to nutraceutical companies intentioned to create new cocktails for keeping the membrane functionality at best.